More serious but rare risks include pancreatitis, gallbladder disease, and potential dehydration leading to acute kidney injury with severe gastrointestinal effects
Weight Loss with GLP-1 Medicines Does Not Result in a Disproportionate Loss of Muscle Mass or Function in Obese Mice and Humans. Cell Reports
Akilesh, S., Christianson, G
PMC 9556320
Additionally, -- offers cardiovascular protection by reducing the risk of heart disease , improving lipid profiles , and providing anti-inflammatory effects , further protecting vascular health
While cardiovascular outcome data for retatrutide is still accumulating, the prudent approach for anyone with active cardiovascular disease is to remain on compounds with established cardiovascular safety profiles