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Dosing starts low and increases gradually over several months to improve tolerability

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By engaging two independent hormone pathways, tirzepatide produces stronger glucose control, more aggressive appetite suppression, and greater weight loss in head-to-head trials

Diabetologia 62:665675 Bergmann NC et al (2020) No acute effects of exogenous glucose-dependent insulinotropic polypeptide on energy intake, appetite, or energy expenditure when added to treatment with a long-acting glucagon-like peptide 1 receptor agonist in men with type 2 diabetes

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When excessive hunger strikes between intervals, modest healthy snacks can be supplemented to stabilize blood glucose fluctuations and ease uncomfortable hunger pangs