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Thus, three HR1 helices of trimeric S2 interact with the pairing HR2 helices and constitute a stable six-helix bundle 23

238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD

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Cell 161 , 15271538 (2015)

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Common causes of knee pain include: Osteoarthritis : The most frequent culprit, where cartilage gradually breaks down over time Meniscus tears : Damage to the shock-absorbing cartilage in your knee Tendinosis : Chronic degeneration of tendons around the knee Ligament injuries : Sprains or tears in the supportive structures Inflammatory conditions : Including rheumatoid arthritis and lupus Referred pain : Sometimes hip problems can cause knee discomfort Traditional treatments typically involve anti-inflammatory medications, physical therapy, steroid injections, or in severe cases, surgery