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Hence, the application of nanotechnology could enhance the efficacy and improve their bioavailability by increasing solubility, enhancing plasma half-life, preventing degradation in the intestinal environment, and elevating permeation in the small intestine (Hu et al., 2017)

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Stimulation of bFLS with bTNF- (100 ng/ml) for 6 h resulted in increased of expression and synthesis of IL-6 and IL-8 (Fig