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We monitored ROS production, modifications in mitochondrial area and respiratory parameters from macrophages following sUA stimulus and observed that sUA is released in a hypoxic environment and, when the first signal of inflammasome activation is present, is able to trigger NLRP3 through the production of mitochondrial ROS
Each aliquot is dispensed into vials and then freeze-dried , after which the vials are flushed with nitrogen to remove residual moisture and contaminants
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