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The phase 2b and phase 3 studies of the mTOR inhibitor RTB101 showed that RTB101 could improve immune function in older adults (NCT03373903, ACTRN12619000628145)

A critical innovation driven by this molecular focus is the development of liquid biopsy, a minimally invasive technique that analyzes tumor-derived material, such as circulating tumor DNA (ctDNA), in bodily fluids [16, 27]

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How the cell is protected from the damage caused by ER-generated ROS is poorly understood