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Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia

10.1186/s43556-023-00131-5 33 de Alcantara SantosR.GuzzoniV.SilvaK

This suggests either active metabolite formation, tissue retention of bioactive fragments, or persistent activation of downstream signaling cascades

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If you eat dinner early (56 p.m.) and inject at 89 p.m., you avoid taking the medication on a full stomach, which some research suggests reduces gastrointestinal upset

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