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It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage

STEP 1 showed 14.9% total weight loss with reduction in both visceral and subcutaneous fat

doi: 10.1371/journal.pbio.1000479

del Pinal F, Garcia-Bernal FJ, Regalado J, Studer A, Ayala H, Cagigal L

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Histopathological analysis confirms that tumor cell accumulation is localized within the dissolving hydrogel, while adjacent neural parenchyma remains unperturbed