Quantitatively, the LSc represents an area with some of the highest numbers of GLP-1Rs (12, 53), but here the GLP-1R expression is predominantly on neuronal projections, which could explain the lack of activation in this region
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Chaudhary R, Liu B, Bensalem J, Sargeant TJ, Page AJ, Wittert GA et al (2022) Intermittent fasting activates markers of autophagy in mouse liver
Third, the study only included Japanese patients, limiting the generalizability of the results to other populations
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However, this medication carries a risk of birth defects, so effective contraception is strongly recommended during its use