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[4] A more potent, binding-protein-resistant analog such as IGF-1 LR3 would, by mechanism, be expected to retain this hypoglycemic potential, and because it evades the buffering system that normally tempers free IGF-1 activity, the metabolic effect could in principle be less predictable

"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity

10.1056/nejm199901143400207 126 SabetghadamM.MazdehM.AbolfathiP.MohammadiY.MehrpooyaM

One of the best ways to stimulate production of GLP-1 in your body is by consuming fiber

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