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Pharmacokinetics of Gabapentin Gabapentin is absorbed via a saturable L-amino acid transporter system in the gut, which means bioavailability actually decreases as the dose increases: roughly 60% at 300 mg three times daily and closer to 35% at 1,600 mg three times daily [3]

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Medication use, including antibiotics and non-steroidal anti-inflammatory drugs

The risk increases with age

The presence of a local nasal condition, such as inflammation or congestion, can interfere with the absorption and distribution of the medication throughout the body

[2,9] This connection between gut-derived peptides and neurological function is an active area of investigation