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This review searched literature published between 2005 and 2021 using keywords cytokines, chemokines, protein targets, small molecular metabolites, and epigenetics, and summarizes recent advances in these novel targets

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Standards of sizes 66, 146, 480 and 1048 kDa were used to fit the calibration curve with an R2 value of 99% and an error of 7.2%

By exploring the molecular basis and functional versatility of mRNA, siRNA, miRNA, ASOs, and RNA aptamers, it elucidates how these strategies are engineered to overcome challenges in delivery, stability, specificity, and immunogenicity