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Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues

Using them together isn't necessarily bad, but it can overwhelm sensitive skin

Additionally, it facilitates fat absorption by the cells

This can be assessed by recalculating static prognostic models after a short period or by using the Lille model, which measures treatment response

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