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A significant proportion (up to 70 %) discontinue GLP-1 treatment within one year

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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

[DOI] [PubMed] [Google Scholar] 31.Chan TS, OBrian PJ

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