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Other conditions that may cause similar symptoms include: Anal fissures: Small tears in the lining of the anus caused by passing hard stools

In the current study, depriving RPE cells of the essential GSH precursor Cys 2 by culturing cells in Cys 2 -free culture medium or blocking de novo synthesis of GSH by using GCL inhibitor BSO or blocking Cys 2 uptake by pharmaceutical inhibition of system x c caused cell death

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For 5-FU treatments, cells were treated with 5-FU (15 M) or DMSO control (0.001%) for 6 h prior to irradiation