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However, a significant reduction in left atrial volume [mean difference 8.7 mL ( 14.2, 3.2), P = 0.002] and in E/e ratio [mean difference 1.4 ( 2.7, 0.1), P = 0.03] [52] was reported

Cardiovascular safety, long-term noncardiovascular safety, and efficacy of sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: a systemic review and meta-analysis with trial sequential analysis

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A Comprehensive Metabolic Panel (CMP) measures glucose, electrolytes, kidney-related markers, liver-related markers, calcium, albumin, total protein, and other routine chemistries

The B12 component does not change the temperature sensitivity