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Complete loss of GPX4 is incompatible with viability, and pharmacological or genetic GPX4 inhibition is widely exploited to induce ferroptosis in cells and tissues

This can result in deposition of potentially cytotoxic protein aggregates of amyloid as in other protein aggregation diseases (Aigelsreiter et al

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Glutathione is an important antioxidant and an essential cofactor for antioxidant enzymes, providing protection for functional proteins via the redox buffer for sulfhydryl [8, 9]

doi: 10.3390/ijms19123903 116 ZordokyB

If you experience progressive neurological symptoms (numbness, tingling, difficulty walking), cognitive changes, or severe anaemia, seek urgent GP assessment