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Lixisenatide In pregnant rats receiving twice daily subcutaneous doses of 2.5, 35, or 500 mcg/kg during organogenesis (gestation day 6 to 17), fetuses were present with visceral closure defects (e.g., microphthalmia, bilateral anophthalmia, diaphragmatic hernia) and stunted growth
ROS-induced damage of lipids significantly affects membrane fluidity and permeability
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Transcriptomic profiling revealed sarcopenia-driven liver dysfunction via myokine signaling Given that STZ-induced metabolic disturbances exhibit broad systemic effects due to pancreatic -cell destruction, 26,40 whereas BTX-Amediated muscle atrophy is more localized with minimal extra-muscular impact, 38 the BTX-A model enabled investigation of the direct impact of sarcopenia on MASLD pathogenesis
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