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Roles of serotonin in cravings and dependence include regulating reward responses, influencing impulsivity, and affecting compulsive behaviors related to substance use

J Gerontol A Biol Sci Med Sci 61 (8), 806812

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The primary reason these treatments are often inadequate is the heterogeneous nature of the disease, which involves multiple pathogenic pathways, including follicular occlusion, immune dysregulation, and genetic predisposition [6,7,8]