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In certain embodiments, any otic formulation or composition described herein has less than about 60 colony forming units (CFU), has less than about 50 colony forming units, has less than about 40 colony forming units, has less than about 30 colony forming units of microbial agents per gram of formulation or composition

Some more sensitive compounds don't tolerate the benzyl alcohol preservative well and are better suited to preservative-free sterile water or saline, even though this typically means the reconstituted solution should be used sooner rather than stored for weeks

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