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Systemic HPA axis

Cook for about 2 minutes, until the whites are set

In PD, the essential degeneration process is influenced by several pathophysiological factors, including mitochondrial dysfunction, increased oxidative stress, inflammation, neurotrophic factor deficiency, impairment of the proteasome-autophagia process, and generation of -synuclein oligomers that form the Lewy bodies [2,3,4,5, 43, 44]

An ideal animal model not only exhibits the same symptoms and pathological changes as a human disease but also follows the same sequence of pathological events

The modern hallmarks-of-aging framework makes this clear