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Despite differences in detection sensitivity between positive and negative ion modes, these are primarily attributable to the structural variations in the analyte, but not to ionization mode itself
In A-treated astrocytes, GLP-1 prevented mitochondrial fragmentation, and improved the neuronal supportive ability via cAMP/PKA pathway (188)
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Given the similarities between the brain's and retina's vascular systems, these findings suggest that GLP-1R agonism could also protect the brain's microvasculature, preserving the integrity of the blood-brain barrier and improving cerebral blood flow