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We therefore conclude that MIG-6L negatively regulates DTC-AC levels, consistent with its proposed role as a negative regulator of basement membrane COL IV levels 23,24

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Moreover, patients in the early stages of diabetes development are able to complete more cycles of FAO leading to medium-chain AC production, compared to long-term diabetic patients who succumb to FAO dysfunction (fewer cycles), and as a result produce more long-chain ACs

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According to FDA prescribing information, these effects include nausea (12-30%), diarrhea (7-23%), vomiting (2-11%), constipation (5-17%), and abdominal pain (4-10%), with rates varying by dose and indication

However, excessive or impaired angiogenesis, even if initially compensatory, can become pathological, exacerbating neurodegenerative processes by increasing vascular instability and inflammation (Sweeney et al