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Endoplasmic reticulum (ER) stress Refers to various stresses that lead to protein misfolding and activate the unfolded protein response (UPR)

Biggar RJ, Andersen EW, Wohlfahrt J, Melbye M

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Tirzepatide acts directly on appetite signalling by activating GLP-1 and GIP receptors, increasing satiety, slowing gastric emptying and enhancing insulin secretion

In simple terms: CJC-1295 DAC = longer acting CJC-1295 No DAC = shorter acting DAC changes half-life, exposure, and signaling pattern This is why comparing the two only by name can be misleading