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GLP-1R is a G protein-coupled receptor, or GPCR, that has been widely studied because receptor activation connects extracellular peptide signaling with intracellular pathways such as cyclic AMP generation, protein kinase A signaling, receptor internalization, and downstream transcriptional responses
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75 Taken together, these mixed results suggest that GLP-1 receptor agonists still have a biological rationale for treating Parkinsons disease, but recent phase 3 trials have not yet delivered consistent evidence of disease modification