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Following the progression of the disease to CRPC or under hormonal therapy inhibiting AR function, the GLS isoform switch occurs in favor of the GAC isoform, allowing advanced PCa cells to favor Gln over glucose to sustain the TCA cycle and augmented proliferation [121]

TB4 can upregulate VEGF via HIF-1 stabilization and engage pathways tied to cell survival and matrix remodeling

Polycycl Aromat Comp 24:697712 Hellou J, Beach DG, Erskine S, Marklevitz SA, Saunders L (2010) Balanced fates of pyrene and 1-hydroxypyrene in snails, Ilyanassa obsoleta , exposed to spiked sediments

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You can have the perfect storage conditions, but if you're introducing contaminants with every use, it won't matter