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Minimal Side Effects: Designed to prevent swelling, lumps, and Tyndall effect compared to other fillers

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The GLP-1 and GIP components enhance insulin secretion and sensitivity, while the glucagon component, somewhat paradoxically, does not worsen blood sugar control because its glucose-raising effects are offset by the dominant insulin-enhancing effects of the other two pathways

Their mechanisms are complementary rather than competitive, addressing different aspects of neural plasticity: Dihexa promotes the structural formation of new synaptic connections, while PE-22-28 enhances neuronal excitability and drives neurogenesis

Any discrepancies were resolved by consensus in consultation with a third reviewer (RR)

Currently approved GLP-1 treatments in the UK include injectable semaglutide (Wegovy) and liraglutide (Saxenda), available through specialist NHS services