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HbA1c measures the average blood sugar levels over the past three months, corresponding to the average lifespan of red blood cells (RBCs) and indicating the extent to which the RBCs are "sugar-coated." For reference, the American Diabetes Association (ADA) advises that the target A1C for most adults with diabetes should be below 7%

Interestingly, both metformin and the anti-oxidant, resveratrol, inhibit ROS-associated mitochondria fission (152)

doi:10.2337/db11-0132 51

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Little is known about the association of discontinuation of sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RA) with outcomes in patients with CKD