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[DOI] [PubMed] [Google Scholar] Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P

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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study