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When DOR internalization is significantly inhibited by over-expression of the dominant negative mutant of dynamin (K44E), the desensitization promoted by sustained exposure to DPDPE is not altered (Qiu et al., 2007)
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From the simple equation V = I R, it is obvious that I sc can also be calculated in open-circuit conditions when R and PD are known
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Therapies, including finerenone, incretin-based therapy, SGLT-2 inhibitors, and emerging neuroprotective treatments may met the need for reducing NPDR progression