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Moreover, prenatal folic acid supplementation, particularly before conception and during the first trimester of pregnancy, has been shown to enhance DNA methylation, potentially influencing fetal development and reducing the risk of neural tube defects [78]

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The NMDA receptor complex is an ionic channel and plays a key role in regulating the length of excitatory postsynaptic potential and, consequently, in synaptic plasticity and cognitive functions and triggering excitotoxic processes leading to the death of neurons (Alavez et al