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2 Introduction/background: history of incretin mimetics medications GIP was the first incretin isolated and characterized in the 1970s though most modern therapies focus on GLP-1 [17]

Its approval was preceded by the outcomes of five phase III trials, which are summarized in Tables 1 and 2, each of which compare tirzepatide at 5 mg, 10 mg, and 15 mg to other medications comparing similar clinical endpoints

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