can semaglutide cause weight gain Comparative safety and side effects of and tirzepatide: Implications for clinical decision-making in obesity management Stopping Semaglutide: How to Keep

Phase 1 GLP-1 and GLP-1/GIP receptor agonists should be used as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight maintenance, in: BMI 38 kg/m 2 (or 35 kg/m 2 in ethnic groups known to be at equivalent risk of obesity consequences at lower BMI than White ethnicity), and one or more obesity-related clinical condition, or Edmonton Obesity Staging System stage 3 or 4 (see Box 1

References Bianchi M, et al

Sci Rep 8(1):10574 Chauhan N et al (2022) GSK-3 and its inhibitors in Alzheimers disease: a recent update

For weight management, NICE has approved specific GLP-1 agonists (Saxenda, Wegovy) under defined criteria

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Common experiences may include: Nausea Decreased appetite Mild gastrointestinal discomfort Injection site tenderness These side effects are typically temporary and may subside as the body adjusts to the medication