Bloating or early fullness Food stays in the stomach longer, which can create a tight or pressured feeling
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Timothy Garvey As Healio previous reported from the SURMOUNT-1 randomized controlled trial, adults with obesity and no diabetes lost up to 20.9% of their body weight at 72 weeks with 15 mg tirzepatide
Very limited total safety exposure
Studies using dual-energy X-ray absorptiometry (DXA) show that fat mass loss is the dominant component of weight reduction at this stage
69,90,239,303 Additionally, uric acid has been associated with endothelial dysfunction, which further exacerbates vascular inflammation and contributes to hypertension