Therefore, patients with T2MD are more likely to suffer from several malignancies compared with healthy individuals
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Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported
The clearest contraindications in the FDA labeling are a personal or family history of medullary thyroid carcinoma (MTC), the genetic condition MEN 2, and a known serious allergic reaction to the specific drug
Involvement of brain catecholamines and acetylcholine in growth hormone deficiency states
Emerging therapeutic strategies targeting lactate metabolism, including glycolytic inhibition, lactate transporter blockade, combination with immune checkpoint inhibitors, and epigenetic modulation, such as Kla enzyme inhibitors, could potentially aid in subverting the immunosuppressive TME, augmenting immune infiltration, and potentiating chemotherapeutic efficacy (22, 23)