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Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity

For cellular blue nevus, especially with satellitosis, malignant blue nevus needs to be considered, and when the lesion is on the face, nevus of Ota

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Its quickly broken down by an enzyme called DPP-4, meaning its effects typically last only a few minutes after its released