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Annals of Nutrition and Metabolism , 41 , 242249

Gclc f/f mice were generated as described 30 and crossed with the Rosa26-CreERT2 mouse strain (Jackson Labs, #008463) or Nrf2 f/f mouse strain (Jackson Labs, #025433)

CPP-CAND showed high selectivity and potency in inducing apoptosis in senescent cells by disrupting FOXO4-p53 foci and activating caspase pathways

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Oxidative stress can be relieved by increasing the concentration of antioxidants such as beta-carotene (Dawson 2000), vitamins C (Mandl 2009) and E (Colombo 2010), as well as the mineral selenium (Sanmartin 2011)