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reported elevated IGF-1 expression at day 5 in a rabbit supraspinatus tendon healing model ( Although the timing of IGF-1 upregulation varies across studies, likely due to differences in species, experimental methods, and tendon locations, the consensus is that IGF-1 expression is significantly elevated during tendon healing

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This recent attention to biological molecules is warranted, since some of the warmest identified ice nucleators are of biological origin 2,28,29

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