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it is available on prescription at 120 mg (Xenical) and over the counter at 60 mg (alli) for adults with a BMI of 28 kg/m or above (OTC) or 30 kg/m or above on prescription, with lower thresholds applying where weight-related comorbidities are present

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In 2006, for example, a new drug for treating rheumatoid arthritis passed animal safety tests but caused severe, life-threatening reactions when given to healthy human volunteers

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If you plan to stop, its typically advised to taper down the dose rather than stopping suddenly, to potentially mitigate appetite rebound (though theres no strict physiological dependence, its more of a precaution)