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Endocrinology (2014) 155(8):293241.10.1210/en.2014-1063 90 TravisMAvan der FlierAKammererRAMouldAPSonnenbergAHumphriesMJ

For example, the viral antigen is typically a recombinant protein rather than native protein from the viral membrane, the density of antigen molecules on the beads (which may be crucial for activation of antibody effector functions) may differ greatly from that on a virion, the size of beads is likely to be different from the size of virions and the phagocytosing cell line may have important differences from primary cells

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