Research into triple-agonist peptides such as Retatrutide has expanded significantly since 2020, with published Phase 2 data (Jastreboff et al., 2023, New England Journal of Medicine) indicating substantial effects in human clinical trials on body weight and glycaemic parameters
Dont believe the hype
S., Vucicevic, L
and round and round it goes
Every patient is unique, so our team will assess your health history, weight loss goals, and overall suitability for these medications during your consultation
Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)