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If your pharmacy includes B12 at a lower concentration, you may want to supplement with additional oral or sublingual B12 between injections, especially at lower semaglutide doses where injection volume (and therefore B12 delivery) is minimal

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However, some users report better tolerability with tirzepatide, possibly due to the GIP component modulating GLP-1 effects

If small particles remain, place the vial in the refrigerator and check again in 15 to 20 minutes