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Interestingly, research has shown that even in animals lacking beta-3 adrenergic receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting additional metabolic pathways may be involved beyond the primary beta-3 receptor mechanism

J Hum Genet 61 , 669672 (2016)

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Cells in the lining of the stomach produce intrinsic factors, and if these cells are damaged or if the stomach is otherwise unable to produce it, vitamin B12 absorption can be impaired