In the STEP trials, which evaluated semaglutide for weight loss, headaches were typically mild to moderate in severity and often resolved within the first 2-4 weeks as the body adjusted to the medication
Surgical Risk: The use of GLP-1s can slow stomach emptying, which may pose risks (e.g., aspiration) during anesthesia if the medication is not paused prior to surgery
Patients report improvements in joint mobility, reduced morning stiffness, and better overall energy levels after starting semaglutidebenefits that extend beyond the scale
The guidelines state, Anesthesiologists should recognize that these conditions can increase the likelihood of regurgitation and pulmonary aspiration and should modify these guidelines based upon their clinical judgment. A previous version states, The guidelines may not apply to, or may need to be modified for, patients with coexisting diseases or conditions that can affect gastric emptying or fluid volume (e.g., pregnancy, obesity, diabetes, hiatal hernia, gastroesophageal reflux disease, ileus or bowel obstruction, emergency care, or enteral tube feeding) and patients in whom airway management might be difficult. Requiring patients to abstain from food for longer than 8 hours, even if the optimal duration was unknown, would have been the most cautious approach, even if it was unenjoyable for patients
Four studies, including 41,225 exposed pregnancies and 232,786 comparator pregnancies, also reported no statistically significant increase in preterm birth (OR 1.17
With more than 5 million patients receiving the drugs that year, the numbers suggest a rate of fewer than four ER visits for adverse events per 1,000 users -- a quite small percentage by any measure
