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Second, its relatively small size and amphiphilic character allow partial blood-brain barrier transit, but enzymatic degradation in plasma competes with CNS entry at every moment after injection

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doi:10.1111/nyas.12973 Schmidt, J., Rinaldi, S., Scalbert, A

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Blood 104(12):36643671 Halwachs-Baumann G, Genser B, Pailer S, Engele H, Rosegger H, Schalk A, Kessler HH, Truschnig-Wilders M (2002) Human cytomegalovirus load in various body fluids of congenitally infected newborns