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While Phase II trials in heart failure and primary mitochondrial myopathy did not meet primary efficacy endpoints, the TAZPOWER trial in Barth syndrome demonstrated significant improvements in muscle strength and sixminute walk distance, leading to FDA accelerated approval in 2025 [3][10]
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Every few years, a new molecule emerges that doesn't just incrementally improve upon the last oneit represents a significant, sometimes dramatic, shift in potential
Muscle pain affects approximately 2-5% of patients taking tirzepatide, typically emerging within the first 4-8 weeks of treatment as the body adjusts to the medication
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