cga and l carnitine and egcg Carnitine: Genetic Variants Affecting Mitochondrial Energy Health Frontiers | Caffeine and EGCG

Oncologist 2013

Without this, the interpretation of biological results would be methodologically too weak

Wang, L., Niu, H

Glutathione Peroxidases Glutathione peroxidases (Gpx) are selenium-containing enzymes that degrade hydrogen peroxide and hydroperoxides to water and to alcohols, respectively, by using an active site seleno-cysteine that is transformed into the selenenic (Se-OH) oxidized form and is reduced back to the selenolate (Se-H) form by glutathione

Whether this mechanism is commonly employed for a variety of substrates and whether monothiol mechanisms (i) and (ii) are really relevant for the reduction of other non-glutathione disulfide substrates remains to be analyzed

Selectivity for the substrates is determined by high variations in hydrophobic amino acid residues in the cleft between domains, called the H-site [208]