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Primary leukemic cells were obtained from de novo diagnosed AML patients

Mice bearing RagA-RagB- or Rheb1-Rheb2-deficient Treg cells developed a Scurfy -like autoimmune disease and have reduced effector Treg cell accumulation and function ( Unlike most other essential amino acids, BCAAs catabolism is initially catalyzed either by transamination by branched-chain amino acid aminotransferases (BCAT) or decarboxylation by branched-chain -keto acid dehydrogenase enzyme complex (BCKDC)

[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Sekhar R.V

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