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Across registered trials, retatrutide has produced the largest weight reductions reported for an incretin-class compound roughly 24% at 12 mg over 48 weeks in phase 2 [1], extended to about 2829% over 6880 weeks in the phase 3 TRIUMPH topline [5], alongside lower HbA1c in type 2 diabetes and large falls in liver-fat content

What happens to antihypertensive medications during weight loss Patients on baseline antihypertensives commonly experience clinically meaningful BP improvement as weight loss progresses

This can result in improved blood sugar control, weight loss, and reduced cardiovascular risk factors

From there, recommendations are made clearly and practically.