FIGURE 2 3 The activation mechanism of eryptosis in renal anemia In the uremic milieu of CKD, a constellation of factorsincluding uremic toxin accumulation, chronic inflammation, oxidative stress, and hypoxiaconverge to induce cellular damage signals that promote eryptosis, the programmed death of erythrocytes
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If GSH peroxidase activity is deficient, lipid peroxidation could increase in the tissues, leading to increased stimulation of PGH synthase, increased thromboxane production, and further increase lipid peroxides
Additionally, glutathione supports the activity of other antioxidants, such as vitamins C and E, helping to regenerate them after they have been oxidised
11c), photolytic (Fig
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